Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease

Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease

Decades of research attempting to slow the onset of Alzheimer's disease (AD) indicates that a better understanding of memory will be key to the discovery of effective therapeutic approaches. Here, we ask whether prodromal neural network dysfunction might occur in the hippocampal trisynaptic cir...

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Bibliographic Details
Main Authors: Marcia H. Ratner, Scott S. Downing, Ouyang Guo, KathrynAnn E. Odamah, Tara M. Stewart, Vidhya Kumaresan, R. Jonathan Robitsek, Weiming Xia, David H. Farb
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Heliyon
Subjects:
Hippocampus
Memory
Consolidation
Place cells
Ripples
Extra-synaptic
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021019988

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http://www.sciencedirect.com/science/article/pii/S2405844021019988

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