Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice

Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice

Sjögren syndrome (SS) is an immunologically complex, chronic autoimmune disease targeting lacrimal and salivary glands. Nonobese diabetic (NOD) mice spontaneously develop inflammation of lacrimal and salivary glands with histopathological features similar to SS in humans including focal lymphocytic...

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Bibliographic Details
Main Authors: Ivy L. Debreceni, Michael S. Chimenti, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Scott M. Lieberman
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Sjögren syndrome
type 1 diabetes
Toll-like receptor 7
lacrimal gland
salivary gland
Online Access:https://www.mdpi.com/1422-0067/21/24/9478

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https://www.mdpi.com/1422-0067/21/24/9478

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