Using DNA methylation patterns to infer tumor ancestry.

Exactly how human tumors grow is uncertain because serial observations are impractical. One approach to reconstruct the histories of individual human cancers is to analyze the current genomic variation between its cells. The greater the variations, on average, the greater the time since the last clo...

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Bibliographic Details
Main Authors: You Jin Hong, Paul Marjoram, Darryl Shibata, Kimberly D Siegmund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2918495?pdf=render