Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

Abstract Estradiol (E2) and the oestrogen receptor-alpha (ERα) signalling pathway play pivotal roles in the proliferative activity of breast cancer cells. Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-PHB2) complex plays a crucial role i...

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Bibliographic Details
Main Authors: Tetsuro Yoshimaru, Keisuke Aihara, Masato Komatsu, Yosuke Matsushita, Yasumasa Okazaki, Shinya Toyokuni, Junko Honda, Mitsunori Sasa, Yasuo Miyoshi, Akira Otaka, Toyomasa Katagiri
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01951-6

Internet

https://doi.org/10.1038/s41598-017-01951-6

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