Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation

l-Ascorbic acid (vitamin C, AA) is known as an antioxidant, but at high concentrations, AA can kill cancer cells through a prooxidant property. Sodium-dependent vitamin C transporter family-2 (SVCT-2) determines the cellular uptake of AA, and the activity of SVCT-2 is directly related to the antican...

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Bibliographic Details
Main Authors: Sungrae Cho, Jin Sung Chae, Hocheol Shin, Yujeong Shin, Youngwook Kim, Eui-Joon Kil, Hee-Seong Byun, Sang-Ho Cho, Seyeon Park, Sukchan Lee, Chang-Hwan Yeom
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523319302542