High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2

High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2

To investigate the role of hepatic 18-carbon fatty acids (FA) accumulation in regulating CYP2A5/2A6 and the significance of Nrf2 in the process during hepatocytes steatosis, Nrf2-null, and wild type mice fed with high-fat diet (HFD), and Nrf2 silenced or over expressed HepG2 cells administered with...

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Bibliographic Details
Main Authors: Xing-he Wang, Xiao-xu Cui, Xiao-qi Sun, Xing-hui Wang, Xiao-chong Li, Yue Qi, Wei Li, Mei-yu Han, Ishfaq Muhammad, Xiu-ying Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
18-carbon fatty acid
CYP2A5
CYP2A6
Nrf2
high-fat diet
hepatocyte steatosis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00233/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00233/full

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