Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors

Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors

Abstract Background HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response to therapy with protease inhibitors are found in the protease’s active...

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Bibliographic Details
Main Authors: Tomas Bastys, Vytautas Gapsys, Hauke Walter, Eva Heger, Nadezhda T. Doncheva, Rolf Kaiser, Bert L. de Groot, Olga V. Kalinina
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Retrovirology
Subjects:
Alchemical binding free energy change calculation
Distant site mutations
HIV-1 protease inhibitors
Hydrogen bond network perturbation
Resistance-associated mutations
Online Access:http://link.springer.com/article/10.1186/s12977-020-00520-6

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http://link.springer.com/article/10.1186/s12977-020-00520-6

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