Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
Abstract Background HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response to therapy with protease inhibitors are found in the protease’s active...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-05-01
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Series: | Retrovirology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12977-020-00520-6 |