Enhancing the Physiochemical Properties of Puerarin via L-Proline Co-Crystallization: Synthesis, Characterization, and Dissolution Studies of Two Phases of Pharmaceutical Co-Crystals

Enhancing the Physiochemical Properties of Puerarin via L-Proline Co-Crystallization: Synthesis, Characterization, and Dissolution Studies of Two Phases of Pharmaceutical Co-Crystals

Puerarin (PUE) is a Chinese traditional medicine known to enhance glucose uptake into the insulin cells to downregulate the blood glucose levels in the treatment of type II diabetes. Nevertheless, the bioavailability of pristine PUE is limited due to its poor solubility and low intestinal permeabili...

Full description

Bibliographic Details
Main Authors: Muhammad Inam, Lu Liu, Jianwei Wang, Kaxi Yu, Chi-Uyen Phan, Jie Shen, Wenhua Zhang, Guping Tang, Xiurong Hu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
puerarin
L-proline
pharmaceutical co-crystal
crystal structure
solubility and dissolution rate
Chinese traditional medicine
Online Access:https://www.mdpi.com/1422-0067/22/2/928

Internet

https://www.mdpi.com/1422-0067/22/2/928

Similar Items