eIF2α phosphorylation: A hallmark of immunogenic cell death

eIF2α phosphorylation: A hallmark of immunogenic cell death

Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α....

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Bibliographic Details
Main Authors: Lucillia Bezu, Allan Sauvat, Juliette Humeau, Marion Leduc, Oliver Kepp, Guido Kroemer
Format: Article
Language:English
Published: Taylor & Francis Group 2018-06-01
Series:OncoImmunology
Subjects:
anthracyclines
cancer
chemotherapy
er stress
unfolded protein response
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1431089

Internet

http://dx.doi.org/10.1080/2162402X.2018.1431089

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