Inhibition of topoisomerase IIα and induction of DNA damage in cholangiocarcinoma cells by altholactone and its halogenated benzoate derivatives

Inhibition of topoisomerase IIα and induction of DNA damage in cholangiocarcinoma cells by altholactone and its halogenated benzoate derivatives

Topoisomerase IIα enzyme (Topo IIα) plays a critical function in DNA replication process and is considered to be a promising target of anti-cancer drugs. In the present study, we reported that the altholactone derivatives modified by adding a halogenated benzoate group showed greater inhibitory acti...

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Bibliographic Details
Main Authors: Sarunya Kitdumrongthum, Somrudee Reabroi, Kanoknetr Suksen, Patoomratana Tuchinda, Bamroong Munyoo, Panupong Mahalapbutr, Thanyada Rungrotmongkol, Puey Ounjai, Arthit Chairoungdua
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Altholactone
Halogenated benzoate
Cholangiocarcinoma
Topoisomerase IIα
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303413

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220303413

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