Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats.

Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats.

Mineralocorticoid receptor (MR) antagonists attenuate renal injury in salt-sensitive hypertensive rats with low plasma aldosterone levels. We hypothesized that oxidative stress causes MR activation in high-salt-fed Dahl salt-sensitive rats. Furthermore, we determined if MR activation persisted and i...

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Bibliographic Details
Main Authors: Kento Kitada, Daisuke Nakano, Ya Liu, Yoshihide Fujisawa, Hirofumi Hitomi, Yuki Shibayama, Hirotaka Shibata, Yukiko Nagai, Hirohito Mori, Tsutomu Masaki, Hiroyuki Kobori, Akira Nishiyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3404044?pdf=render

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http://europepmc.org/articles/PMC3404044?pdf=render

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