Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging

Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging

Contacts between mitochondria and endoplasmatic reticulum (ER), and the transfer of calcium between them, have an important role in the regulation of cellular phenotypes, including senescence. Here the authors show that ITPR2 deficient mice display improved aging, associated with a decreased number...

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Bibliographic Details
Main Authors: Dorian V. Ziegler, David Vindrieux, Delphine Goehrig, Sara Jaber, Guillaume Collin, Audrey Griveau, Clotilde Wiel, Nadia Bendridi, Sophia Djebali, Valerio Farfariello, Natacha Prevarskaya, Léa Payen, Jacqueline Marvel, Sébastien Aubert, Jean-Michel Flaman, Jennifer Rieusset, Nadine Martin, David Bernard
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-20993-z

Internet

https://doi.org/10.1038/s41467-021-20993-z

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