Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging

Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging

Contacts between mitochondria and endoplasmatic reticulum (ER), and the transfer of calcium between them, have an important role in the regulation of cellular phenotypes, including senescence. Here the authors show that ITPR2 deficient mice display improved aging, associated with a decreased number...

Full description

Bibliographic Details
Main Authors: Dorian V. Ziegler, David Vindrieux, Delphine Goehrig, Sara Jaber, Guillaume Collin, Audrey Griveau, Clotilde Wiel, Nadia Bendridi, Sophia Djebali, Valerio Farfariello, Natacha Prevarskaya, Léa Payen, Jacqueline Marvel, Sébastien Aubert, Jean-Michel Flaman, Jennifer Rieusset, Nadine Martin, David Bernard
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-20993-z
id doaj-7e2b02f88245449d9aaaf2f356575379
record_format Article
spelling doaj-7e2b02f88245449d9aaaf2f3565753792021-02-07T12:12:28ZengNature Publishing GroupNature Communications2041-17232021-02-0112111210.1038/s41467-021-20993-zCalcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and agingDorian V. Ziegler0David Vindrieux1Delphine Goehrig2Sara Jaber3Guillaume Collin4Audrey Griveau5Clotilde Wiel6Nadia Bendridi7Sophia Djebali8Valerio Farfariello9Natacha Prevarskaya10Léa Payen11Jacqueline Marvel12Sébastien Aubert13Jean-Michel Flaman14Jennifer Rieusset15Nadine Martin16David Bernard17Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCarMeN Laboratory, INSERM UMR-1060, Lyon 1 University, INRA U1397Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université de Lyon, Université Claude Bernard Lyon 1INSERM U1003, Laboratoire d’Excellence, Canaux Ioniques d’Intérêt Thérapeutique, Équipe Labellisée Par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de LilleINSERM U1003, Laboratoire d’Excellence, Canaux Ioniques d’Intérêt Thérapeutique, Équipe Labellisée Par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de LilleCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCentre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université de Lyon, Université Claude Bernard Lyon 1Institut de Pathologie, Centre de Biologie Pathologie, CHRU de Lille, Faculté de Médecine, Université de LilleCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCarMeN Laboratory, INSERM UMR-1060, Lyon 1 University, INRA U1397Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonCentre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de LyonContacts between mitochondria and endoplasmatic reticulum (ER), and the transfer of calcium between them, have an important role in the regulation of cellular phenotypes, including senescence. Here the authors show that ITPR2 deficient mice display improved aging, associated with a decreased number of contacts between the mitochondria and the ER.https://doi.org/10.1038/s41467-021-20993-z
collection DOAJ
language English
format Article
sources DOAJ
author Dorian V. Ziegler
David Vindrieux
Delphine Goehrig
Sara Jaber
Guillaume Collin
Audrey Griveau
Clotilde Wiel
Nadia Bendridi
Sophia Djebali
Valerio Farfariello
Natacha Prevarskaya
Léa Payen
Jacqueline Marvel
Sébastien Aubert
Jean-Michel Flaman
Jennifer Rieusset
Nadine Martin
David Bernard
spellingShingle Dorian V. Ziegler
David Vindrieux
Delphine Goehrig
Sara Jaber
Guillaume Collin
Audrey Griveau
Clotilde Wiel
Nadia Bendridi
Sophia Djebali
Valerio Farfariello
Natacha Prevarskaya
Léa Payen
Jacqueline Marvel
Sébastien Aubert
Jean-Michel Flaman
Jennifer Rieusset
Nadine Martin
David Bernard
Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
Nature Communications
author_facet Dorian V. Ziegler
David Vindrieux
Delphine Goehrig
Sara Jaber
Guillaume Collin
Audrey Griveau
Clotilde Wiel
Nadia Bendridi
Sophia Djebali
Valerio Farfariello
Natacha Prevarskaya
Léa Payen
Jacqueline Marvel
Sébastien Aubert
Jean-Michel Flaman
Jennifer Rieusset
Nadine Martin
David Bernard
author_sort Dorian V. Ziegler
title Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
title_short Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
title_full Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
title_fullStr Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
title_full_unstemmed Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
title_sort calcium channel itpr2 and mitochondria–er contacts promote cellular senescence and aging
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description Contacts between mitochondria and endoplasmatic reticulum (ER), and the transfer of calcium between them, have an important role in the regulation of cellular phenotypes, including senescence. Here the authors show that ITPR2 deficient mice display improved aging, associated with a decreased number of contacts between the mitochondria and the ER.
url https://doi.org/10.1038/s41467-021-20993-z
work_keys_str_mv AT dorianvziegler calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT davidvindrieux calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT delphinegoehrig calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT sarajaber calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT guillaumecollin calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT audreygriveau calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT clotildewiel calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT nadiabendridi calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT sophiadjebali calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT valeriofarfariello calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT natachaprevarskaya calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT leapayen calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT jacquelinemarvel calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT sebastienaubert calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT jeanmichelflaman calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT jenniferrieusset calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT nadinemartin calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
AT davidbernard calciumchannelitpr2andmitochondriaercontactspromotecellularsenescenceandaging
_version_ 1714881810227265536

Similar Items