MicroRNA-34a Attenuates Paclitaxel Resistance in Prostate Cancer Cells via Direct Suppression of JAG1/Notch1 Axis

MicroRNA-34a Attenuates Paclitaxel Resistance in Prostate Cancer Cells via Direct Suppression of JAG1/Notch1 Axis

Background/Aims: Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically centered on paclitaxel-based chemotherapy. In this study, we aimed to evaluate whether miR-34a attenuates chemoresistance to paclitaxel by regulating target genes associated with dr...

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Bibliographic Details
Main Authors: Xiaobing Liu, Xing Luo, Yuqi Wu, Ding Xia, Wei Chen, Zhenqiang Fang, Jianping Deng, Yaxing Hao, Xia Yang, Teng Zhang, Luqiang Zhou, Yingbing Wu, Qingqing Wang, Jie Xu, Xiaoyan Hu, Longkun Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
miR-34a s
Chemoresistance
Paclitaxel
Prostate cancer
JAG1
Notch1
Online Access:https://www.karger.com/Article/FullText/494004

Internet

https://www.karger.com/Article/FullText/494004

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