Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)

Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)

Parkinson’s disease (PD), Alzheimer’s disease (AD) and Amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases hallmarked by the formation of toxic protein aggregates. However, targeting these aggregates therapeutically have thus far shown no success. The treatment of AD has remained part...

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Bibliographic Details
Main Authors: Kirsten Jenkins, Teodora Mateeva, István Szabó, Andre Melnik, Paola Picotti, Attila Csikász-Nagy, Edina Rosta
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Data integration
Molecular dynamics (MD)
Neurodegenerative diseases
Parkinson’s disease (PD)
Synaptojanin-1
α-Synuclein
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020300428

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http://www.sciencedirect.com/science/article/pii/S2001037020300428

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