Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)
Parkinson’s disease (PD), Alzheimer’s disease (AD) and Amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases hallmarked by the formation of toxic protein aggregates. However, targeting these aggregates therapeutically have thus far shown no success. The treatment of AD has remained part...
Main Authors: | Kirsten Jenkins, Teodora Mateeva, István Szabó, Andre Melnik, Paola Picotti, Attila Csikász-Nagy, Edina Rosta |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-01-01
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Series: | Computational and Structural Biotechnology Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037020300428 |
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