MicroRNA-96 directly inhibits γ-globin expression in human erythropoiesis.

MicroRNA-96 directly inhibits γ-globin expression in human erythropoiesis.

Fetal hemoglobin, HbF (α(2)γ(2)), is the main hemoglobin synthesized up to birth, but it subsequently declines and adult hemoglobin, HbA (α(2)β(2)), becomes predominant. Several studies have indicated that expression of the HbF subunit γ-globin might be regulated post-transcriptionally. This could b...

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Bibliographic Details
Main Authors: Imane Azzouzi, Hansjoerg Moest, Jeannine Winkler, Jean-Claude Fauchère, André P Gerber, Bernd Wollscheid, Markus Stoffel, Markus Schmugge, Oliver Speer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3145767?pdf=render

Internet

http://europepmc.org/articles/PMC3145767?pdf=render

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