New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity

New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity

New analogs of nortopsentin, a natural 2,4-bis(3′-indolyl)imidazole alkaloid, in which the central imidazole ring of the natural lead was replaced by a 1,2,4-oxadiazole moiety, and in which a 7-azaindole portion substituted the original indole moiety, were efficiently synthesized. Among al...

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Bibliographic Details
Main Authors: Stella Cascioferro, Alessandro Attanzio, Veronica Di Sarno, Simona Musella, Luisa Tesoriere, Girolamo Cirrincione, Patrizia Diana, Barbara Parrino
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Marine Drugs
Subjects:
marine alkaloids
nortopsentin analogs
1,2,4-oxadiazole derivatives
anti-cancer agents
antiproliferative activity
Online Access:http://www.mdpi.com/1660-3397/17/1/35

Internet

http://www.mdpi.com/1660-3397/17/1/35

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