Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma

Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma

Despite recent advances in therapy, liver metastasis from melanoma is still associated with poor prognosis. Although targeting the mTOR signaling pathway exerts potent anti-tumor activity, little is known about specific mTORC2 inhibition regarding liver metastasis. Using the novel mTORC2 specific in...

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Bibliographic Details
Main Authors: Jessica Guenzle, Harue Akasaka, Katharina Joechle, Wilfried Reichardt, Aina Venkatasamy, Jens Hoeppner, Claus Hellerbrand, Stefan Fichtner-Feigl, Sven A. Lang
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
mTORC2
melanoma
migration
metastasis
Online Access:https://www.mdpi.com/1422-0067/22/1/30

Internet

https://www.mdpi.com/1422-0067/22/1/30

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