Hypoacylated LPS from Foodborne Pathogen Campylobacter jejuni Induces Moderate TLR4-Mediated Inflammatory Response in Murine Macrophages

Hypoacylated LPS from Foodborne Pathogen Campylobacter jejuni Induces Moderate TLR4-Mediated Inflammatory Response in Murine Macrophages

Toll-like receptor 4 (TLR4) initiates immune response against Gram-negative bacteria upon specific recognition of lipid A moiety of lipopolysaccharide (LPS), the major component of their cell wall. Some natural differences between LPS variants in their ability to interact with TLR4 may lead to eithe...

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Bibliographic Details
Main Authors: Kirill V. Korneev, Anna N. Kondakova, Ekaterina N. Sviriaeva, Nikita A. Mitkin, Angelo Palmigiano, Andrey A. Kruglov, Georgy B. Telegin, Marina S. Drutskaya, Luisa Sturiale, Domenico Garozzo, Sergei A. Nedospasov, Yuriy A. Knirel, Dmitry V. Kuprash
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
LPS
lipid A
acyl chains
Campylobacter jejuni
pathogenic bacteria
TLR4
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00058/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2018.00058/full

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