GSK-3 as a Target for Lithium-induced Neuroprotection against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

GSK-3 as a Target for Lithium-induced Neuroprotection against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

The mood stabilizer lithium inhibits glycogen synthase kinase-3 (GSK-3) directly or indirectly by enhancing serine phosphorylation of both alpha and beta isoforms. Lithium robustly protected primary brain neurons from glutamate-induced excitotoxicity; these actions were mimicked by other GSK-3 inhib...

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Bibliographic Details
Main Authors: De-Maw eChuang, Zhifei eWang, Chi-Tso eChiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Lithium
Mesenchymal Stem Cells
cerebral ischemia
excitotoxicity
Glycogen Synthase Kinase-3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00015/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00015/full

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