Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae.

Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae.

The chemotherapeutic doxorubicin (DOX) induces DNA double-strand break (DSB) damage. In order to identify conserved genes that mediate DOX resistance, we screened the Saccharomyces cerevisiae diploid deletion collection and identified 376 deletion strains in which exposure to DOX was lethal or sever...

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Bibliographic Details
Main Authors: Tammy J Westmoreland, Sajith M Wickramasekara, Andrew Y Guo, Alice L Selim, Tiffany S Winsor, Arno L Greenleaf, Kimberly L Blackwell, John A Olson, Jeffrey R Marks, Craig B Bennett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2688081?pdf=render

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http://europepmc.org/articles/PMC2688081?pdf=render

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