Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors

Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors

The lipid-metabolizing enzymes remain underexplored in gastrointestinal stromal tumors (GISTs). Through transcriptomic reappraisal, hydroxysteroid 11-beta dehydrogenase-1 (<i>HSD11B1</i>) was identified as a top-upregulated, progression-associated gene. To validate the clinical relevance...

Full description

Bibliographic Details
Main Authors: Chien-Feng Li, Ting-Ting Liu, Jui-Chu Wang, Shih-Chen Yu, Yen-Yang Chen, Fu-Min Fang, Wan-Shan Li, Hsuan-Ying Huang
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Journal of Clinical Medicine
Subjects:
gastrointestinal stromal tumor
metabolism
lipid
transcriptome
HSD11B1
gain
mutation
overexpression
Online Access:https://www.mdpi.com/2077-0383/7/11/408

Internet

https://www.mdpi.com/2077-0383/7/11/408

Similar Items