Current Evidence for a Bidirectional Loop Between the Lysosome and Alpha-Synuclein Proteoforms

Current Evidence for a Bidirectional Loop Between the Lysosome and Alpha-Synuclein Proteoforms

Cumulative evidence collected in recent decades suggests that lysosomal dysfunction contributes to neurodegenerative diseases, especially if amyloid proteins are involved. Among these, alpha-synuclein (aSyn) that progressively accumulates and aggregates in Lewy bodies is undisputedly a main culprit...

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Bibliographic Details
Main Authors: Norelle C. Wildburger, Anna-Sophia Hartke, Alina Schidlitzki, Franziska Richter
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
alpha-synuclein
proteoforms
lysosome
Parkinson disease
GCase
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.598446/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.598446/full

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