The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis

The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis

Osteoarthritis (OA) is a degenerative disease that induces pain, cartilage deformation, and joint inflammation. Mesenchymal stem cells (MSCs) are potential therapeutic agents for treatment of OA. However, MSC therapy can cause excessive inflammation. Signal transducer and activator of transcription...

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Bibliographic Details
Main Authors: Seon-yeong Lee, Seung Hoon Lee, Hyun Sik Na, Ji Ye Kwon, Goo-Young Kim, KyungAh Jung, Keun-Hyung Cho, Seon Ae Kim, Eun Jeong Go, Min-Jung Park, Jin-Ah Baek, Si Young Choi, JooYeon Jhun, Sung-Hwan Park, Seok Jung Kim, Mi-La Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
inflammation
mesenchymal stem cells
stat3
TRPV1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02881/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02881/full

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