Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.

Genetic and biochemical abnormalities of α-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated the in vivo interaction of mouse and human α-synuclein with the potent parkinsonian neurotoxin, MPTP. We find that while lack of mouse α-synucle...

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Bibliographic Details
Main Authors: Bobby Thomas, Allen S Mandir, Neva West, Ying Liu, Shaida A Andrabi, Wanda Stirling, Valina L Dawson, Ted M Dawson, Michael K Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3031616?pdf=render

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http://europepmc.org/articles/PMC3031616?pdf=render

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