Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells

Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells

Abstract Background Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, we explore the impact of the Akt inhibitor MK-2206 alone and in combinat...

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Bibliographic Details
Main Authors: Cholpon S. Djuzenova, Vanessa Fiedler, Simon Memmel, Astrid Katzer, Dmitri Sisario, Philippa K. Brosch, Alexander Göhrung, Svenja Frister, Heiko Zimmermann, Michael Flentje, Vladimir L. Sukhorukov
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Cancer
Subjects:
DNA damage
Glioblastoma Multiforme
Histone H2AX
Irradiation
Migration
mTOR
Online Access:http://link.springer.com/article/10.1186/s12885-019-5517-4

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http://link.springer.com/article/10.1186/s12885-019-5517-4

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