IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma

IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma

Abstract Background Asthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of allergic asthma whether these mice experienced increased morbidity from pandemic H1N1 (pH1N1) viral infection and whether b...

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Main Authors: Kimia Shahangian, David A. Ngan, H. H. Rachel Chen, Yeni Oh, Anthony Tam, Jing Wen, Chung Cheung, Darryl A. Knight, Delbert R. Dorscheid, Tillie L. Hackett, Michael R. Hughes, Kelly M. McNagny, Jeremy A. Hirota, Masahiro Niikura, S. F. Paul Man, Don D. Sin
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Respiratory Research
Online Access:https://doi.org/10.1186/s12931-021-01669-0

Internet

https://doi.org/10.1186/s12931-021-01669-0

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