Fibrosis Distinguishes Critical Limb Ischemia Patients from Claudicants in a Transcriptomic and Histologic Analysis

Fibrosis Distinguishes Critical Limb Ischemia Patients from Claudicants in a Transcriptomic and Histologic Analysis

Most patients with critical limb ischemia (CLI) from peripheral arterial disease (PAD) do not have antecedent intermittent claudication (IC). We hypothesized that transcriptomic analysis would identify CLI-specific pathways, particularly in regards to fibrosis. Derivation cohort data from muscle bio...

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Bibliographic Details
Main Authors: Guangzhi Cong, Xiangdong Cui, Ricardo Ferrari, Iraklis I. Pipinos, George P. Casale, Ansuman Chattopadhyay, Ulka Sachdev
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Journal of Clinical Medicine
Subjects:
peripheral artery disease (PAD)
transcriptomics
fibrosis pathway
claudication
critical limb ischemia (CLI)
Online Access:https://www.mdpi.com/2077-0383/9/12/3974

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https://www.mdpi.com/2077-0383/9/12/3974

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