High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in <i>Pex1</i>-G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment

High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in <i>Pex1</i>-G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment

Genetic alterations in <i>PEX</i> genes lead to peroxisome biogenesis disorder. In humans, they are associated with Zellweger spectrum disorders (ZSD). No validated treatment has been shown to modify the dismal natural history of ZSD. Liver transplantation (LT) improved clinical and bioc...

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Bibliographic Details
Main Authors: Tanguy Demaret, Jonathan Evraerts, Joachim Ravau, Martin Roumain, Giulio G. Muccioli, Mustapha Najimi, Etienne M. Sokal
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
peroxisome biogenesis disorder
Zellweger spectrum disorder
oxysterols
mouse model
PEX1 p.Gly843Asp
PEX1 c.2528G&gt
Online Access:https://www.mdpi.com/2073-4409/10/1/40

Internet

https://www.mdpi.com/2073-4409/10/1/40

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