Innate B-1 B Cells Are Not Enriched in Red Blood Cell Autoimmune Mice: Importance of B Cell Receptor Transgenic Selection

Innate B-1 B Cells Are Not Enriched in Red Blood Cell Autoimmune Mice: Importance of B Cell Receptor Transgenic Selection

Autoimmune hemolytic anemia (AIHA) results from breakdown of humoral tolerance to RBC antigens. Past analyses of B-cell receptor transgenic (BCR-Tg) mice that recognize RBC autoantigens led to a paradigm in which autoreactive conventional B-2 B cells are deleted whereas extramedullary B-1 B cells es...

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Bibliographic Details
Main Authors: Amanda L. Richards, Heather L. Howie, Linda M. Kapp, Jeanne E. Hendrickson, James C. Zimring, Krystalyn E. Hudson
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
B cell tolerance
red blood cells
autoimmunity
autoimmunity models
autoantibodies
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01366/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01366/full

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