Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia

Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for multiple cellular metabolic reactions and has a central role in energy production. Brain ischemia depletes NAD+ pools leading to bioenergetics failure and cell death. Nicotinamide mononucleotide (NMN) is utilized by the NAD+ salva...

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Bibliographic Details
Main Authors: Ji H. Park, Aaron Long, Katrina Owens, Tibor Kristian
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Neurobiology of Disease
Subjects:
Nicotinamide mononucleotide
nicotinamide dinucleotide
poly-ADP-ribose
ischemia
brain
mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301760

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http://www.sciencedirect.com/science/article/pii/S0969996116301760

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