Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

A large diversity of 2-aminoimidazolone alkaloids is produced by various marine invertebrates, especially by the marine Calcareous sponges Leucetta and Clathrina. The phylogeny of these sponges and the wide scope of 2-aminoimidazolone alkaloids they produce are reviewed in this article. The origin (...

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Bibliographic Details
Main Authors: Nadège Loaëc, Eletta Attanasio, Benoît Villiers, Emilie Durieu, Tania Tahtouh, Morgane Cam, Rohan A. Davis, Aline Alencar, Mélanie Roué, Marie-Lise Bourguet-Kondracki, Peter Proksch, Emmanuelle Limanton, Solène Guiheneuf, François Carreaux, Jean-Pierre Bazureau, Michelle Klautau, Laurent Meijer
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Marine Drugs
Subjects:
marine sponge
Porifera
Calcarea
ascidian
Polyandrocarpa
2-aminoimidazolone alkaloids
leucettamine B
leucettine
polyandrocarpamines
protein kinases
DYRK
CLK
kinase inhibitor
Alzheimer’s disease
Down syndrome
Online Access:https://www.mdpi.com/1660-3397/15/10/316

Internet

https://www.mdpi.com/1660-3397/15/10/316

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