Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway

Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway

ObjectivesComplement 1q binding protein (C1QBP/HABP1/p32/gC1qR) has been found to be overexpressed in triple-negative breast cancer (TNBC). However, the underlying mechanisms of high C1QBP expression and its role in TNBC remain largely unclear. Hypoxia is a tumor-associated microenvironment that pro...

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Bibliographic Details
Main Authors: Hao Wu, Yijun Chu, Shanshan Sun, Guozheng Li, Shouping Xu, Xianyu Zhang, Yongdong Jiang, Song Gao, Qin Wang, Jian Zhang, Da Pang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hypoxia
TNBC
C1QBP
metastasis
chemoresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.607142/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.607142/full

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