Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with abnormal progenitor self-renewal and defective white blood cell differentiation. Its pathogenesis comprises subversion of transcriptional regulation, through mutation and by hijacking normal chromatin regulation. Kat2a is a...

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Bibliographic Details
Main Authors: Ana Filipa Domingues, Rashmi Kulkarni, George Giotopoulos, Shikha Gupta, Laura Vinnenberg, Liliana Arede, Elena Foerner, Mitra Khalili, Rita Romano Adao, Ayona Johns, Shengjiang Tan, Keti Zeka, Brian J Huntly, Sudhakaran Prabakaran, Cristina Pina
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
acute myeloid leukaemia
transcriptional heterogeneity
epigenetics
Kat2a
Single-cell RNA seq
transcriptional bursting
Online Access:https://elifesciences.org/articles/51754

Internet

https://elifesciences.org/articles/51754

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