Facile synthesis of 1-alkoxy-1H-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications

Facile synthesis of 1-alkoxy-1H-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications

(1H-Benzo[d][1,2,3]triazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), 1H-benzo[d][1,2,3]triazol-1-yl 4-methylbenzenesulfonate (Bt-OTs), and 3H-[1,2,3]triazolo[4,5-b]pyridine-3-yl 4-methylbenzenesulfonate (At-OTs) are classically utilized in peptide synthesis for amide-bond for...

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Bibliographic Details
Main Authors: Mahesh K. Lakshman, Manish K. Singh, Mukesh Kumar, Raghu Ram Chamala, Vijayender R. Yedulla, Domenick Wagner, Evan Leung, Lijia Yang, Asha Matin, Sadia Ahmad
Format: Article
Language:English
Published: Beilstein-Institut 2014-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkoxy
azabenzotriazole
benzotriazole
peptide-coupling
phosphonium
Online Access:https://doi.org/10.3762/bjoc.10.200

Internet

https://doi.org/10.3762/bjoc.10.200

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