Síntese, avaliação biológica e modelagem molecular de arilfuranos como inibidores da enzima tripanotiona redutase Synthesis, biological evaluation and molecular modeling of arylfurans as potential trypanothione reductase inhibitors

Síntese, avaliação biológica e modelagem molecular de arilfuranos como inibidores da enzima tripanotiona redutase Synthesis, biological evaluation and molecular modeling of arylfurans as potential trypanothione reductase inhibitors

<abstract language="eng">Trypanosoma cruzi is a protozoan parasite that causes a severe disease (Chagas'disease) in Central and South America. The currently available chemotherapeutic agents against this disease are still inadequate. The enzyme trypanothione reductase (TR) is co...

Full description

Bibliographic Details
Main Authors: Renata B. de Oliveira, Carlos L. Zani, Rafaela S. Ferreira, Rodrigo S. Leite, Tânia M. A. Alves, Thaís H. A. da Silva, Alvaro J. Romanha
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2008-01-01
Series:Química Nova
Subjects:
trypanothione reductase
molecular modeling
arylfurans
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200013

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200013

Similar Items