Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

Caveolae are plasma membrane invaginations containing cavin proteins that are disrupted upon stress stimuli, causing cavin release inside the cell. Here, McMahon et al. identify cavin interacting proteins using proteomic analyses and reveal functions in stress signaling that can promote apoptosis.

Bibliographic Details
Main Authors:	Kerrie-Ann McMahon, Yeping Wu, Yann Gambin, Emma Sierecki, Vikas A. Tillu, Thomas Hall, Nick Martel, Satomi Okano, Shayli Varasteh Moradi, Jayde E. Ruelcke, Charles Ferguson, Alpha S. Yap, Kirill Alexandrov, Michelle M. Hill, Robert G. Parton
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11111-1

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spelling	doaj-7e714ae10b044f39b3b19d07f10294862021-05-11T11:48:06ZengNature Publishing GroupNature Communications2041-17232019-07-0110111710.1038/s41467-019-11111-1Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosisKerrie-Ann McMahon0Yeping Wu1Yann Gambin2Emma Sierecki3Vikas A. Tillu4Thomas Hall5Nick Martel6Satomi Okano7Shayli Varasteh Moradi8Jayde E. Ruelcke9Charles Ferguson10Alpha S. Yap11Kirill Alexandrov12Michelle M. Hill13Robert G. Parton14The University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Translational Research InstituteThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland, Institute for Molecular BioscienceThe University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Translational Research InstituteThe University of Queensland, Institute for Molecular BioscienceCaveolae are plasma membrane invaginations containing cavin proteins that are disrupted upon stress stimuli, causing cavin release inside the cell. Here, McMahon et al. identify cavin interacting proteins using proteomic analyses and reveal functions in stress signaling that can promote apoptosis.https://doi.org/10.1038/s41467-019-11111-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kerrie-Ann McMahon Yeping Wu Yann Gambin Emma Sierecki Vikas A. Tillu Thomas Hall Nick Martel Satomi Okano Shayli Varasteh Moradi Jayde E. Ruelcke Charles Ferguson Alpha S. Yap Kirill Alexandrov Michelle M. Hill Robert G. Parton
spellingShingle	Kerrie-Ann McMahon Yeping Wu Yann Gambin Emma Sierecki Vikas A. Tillu Thomas Hall Nick Martel Satomi Okano Shayli Varasteh Moradi Jayde E. Ruelcke Charles Ferguson Alpha S. Yap Kirill Alexandrov Michelle M. Hill Robert G. Parton Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis Nature Communications
author_facet	Kerrie-Ann McMahon Yeping Wu Yann Gambin Emma Sierecki Vikas A. Tillu Thomas Hall Nick Martel Satomi Okano Shayli Varasteh Moradi Jayde E. Ruelcke Charles Ferguson Alpha S. Yap Kirill Alexandrov Michelle M. Hill Robert G. Parton
author_sort	Kerrie-Ann McMahon
title	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis
title_short	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis
title_full	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis
title_fullStr	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis
title_full_unstemmed	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis
title_sort	identification of intracellular cavin target proteins reveals cavin-pp1alpha interactions regulate apoptosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Caveolae are plasma membrane invaginations containing cavin proteins that are disrupted upon stress stimuli, causing cavin release inside the cell. Here, McMahon et al. identify cavin interacting proteins using proteomic analyses and reveal functions in stress signaling that can promote apoptosis.
url	https://doi.org/10.1038/s41467-019-11111-1
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Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

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