Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks

Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks

Background: Seasonal influenza is a major public health concern in vulnerable populations. Here we investigated the safety, tolerability, and pharmacokinetics of a broadly neutralizing monoclonal antibody (VIS410) against Influenza A in a Phase 1 clinical trial. Based on these results and preclinica...

Full description

Bibliographic Details
Main Authors: Andrew M. Wollacott, Maciej F. Boni, Kristy J. Szretter, Susan E. Sloan, Mona Yousofshahi, Karthik Viswanathan, Sylvain Bedard, Catherine A. Hay, Patrick F. Smith, Zachary Shriver, Jose M. Trevejo
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:EBioMedicine
Subjects:
Influenza
Monoclonal antibody
Epidemic modeling
Prophylaxis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416300548

Internet

http://www.sciencedirect.com/science/article/pii/S2352396416300548

Similar Items