Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro
Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on dynein regulators LIS1 and NudE/L, but not on p1...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12259 |