Neuroprotective Effect of Tricyclic Pyridine Alkaloids from <i>Fusarium lateritium</i> SSF2, against Glutamate-Induced Oxidative Stress and Apoptosis in the HT22 Hippocampal Neuronal Cell Line

Neuroprotective Effect of Tricyclic Pyridine Alkaloids from <i>Fusarium lateritium</i> SSF2, against Glutamate-Induced Oxidative Stress and Apoptosis in the HT22 Hippocampal Neuronal Cell Line

Excessive glutamate damages neuronal cells via the accumulation of intracellular reactive oxygen species (ROS), calcium ion (Ca<sup>2+</sup>) influx, depolarization of mitochondrial membrane potential, and apoptosis, which may result in the development of chronic neurodegenerative diseas...

Full description

Bibliographic Details
Main Authors: Dahae Lee, Hyun Gyu Choi, Ji Hye Hwang, Sang Hee Shim, Ki Sung Kang
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
glutamate
oxidative stress
Ca<sup>2+</sup>
apoptosis
HT22 cells
<i>Fusarium lateritium</i> SSF2
Online Access:https://www.mdpi.com/2076-3921/9/11/1115

Internet

https://www.mdpi.com/2076-3921/9/11/1115

Similar Items