Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study

• Main Authors: Leonie Beyer, Johanna Meyer-Wilmes, Sonja Schönecker, Jonas Schnabel, Julia Sauerbeck, Maximilian Scheifele, Catharina Prix, Marcus Unterrainer, Cihan Catak, Oliver Pogarell, Carla Palleis, Robert Perneczky, Adrian Danek, Katharina Buerger, Peter Bartenstein, Johannes Levin, Axel Rominger, Michael Ewers, Matthias Brendel
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: NeuroImage: Clinical
• Subjects: Cognitive reserve; Frontotemporal dementia; FDG-PET; Hypometabolism
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213158220303727

Background and objective: Reserve is defined as the ability to maintain cognitive functions relatively well at a given level of pathology. Early life experiences such as education are associated with lower dementia risk in general. However, whether more years of education guards against the impact of brain alterations also in frontotemporal dementia (FTD) has not been shown in a large patient collective. Therefore, we assessed whether education is associated with relatively high cognitive performance despite the presence of [18F]-fluorodeoxyglucose positron-emission-tomography (FDG-PET) hypometabolism in FTD. Methods: Sixty-six FTD subjects (age 67 ± 8 years) and twenty-four cognitively healthy controls (HC) were evaluated. Brain regions with FTD-related glucose hypometabolism in the contrast against HC and brain regions that correlate with the cognitive function were defined by a voxel-based analysis and individual FDG-PET values were extracted from all frontotemporal brain areas. Linear regression analysis served to test if education is associated with residualized cognitive performance and regional FDG-PET hypometabolism after controlling for global cognition. Results: Compared to healthy controls, patients with FTD showed glucose hypometabolism in bilateral frontal and temporal brain areas whereas cognition was only associated with deteriorated glucose metabolism in the left temporal lobe. The education level was significantly correlated with the residualized cognitive performance (residuals from regression analysis between hypometabolism and cognitive function as a quantitative index of reserve) and also negatively correlated with left temporal FDG-PET hypometabolism after controlling for cognition. Conclusions: In patients with FTD, the education level predicts the existing left temporal FDG-PET hypometabolism at the same cognition level, supporting the cognitive reserve hypothesis in FTD.