Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus.

Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus.

Cell culture-adapted strains of Sindbis virus (SINV) initially attach to cells by the ability to interact with heparan sulfate (HS) through selective mutation for positively charged amino acid (aa) scattered in E2 glycoprotein (W. B. Klimstra, K. D. Ryman, and R. E. Johnston, J. Virol. 72: 7357-7366...

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Bibliographic Details
Main Authors: Wuyang Zhu, Lihua Wang, Yiliang Yang, Juan Jia, Shihong Fu, Yun Feng, Ying He, Jin-Ping Li, Guodong Liang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2836379?pdf=render

Internet

http://europepmc.org/articles/PMC2836379?pdf=render

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