Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors

Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors

Acetyl-coenzyme A carboxylases (ACCs) play critical roles in the regulation of fatty acid metabolism and have been targeted for the development of drugs against obesity, diabetes and other metabolic diseases. Two series of compounds possessing quinoline moieties were designed, synthesized and evalua...

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Bibliographic Details
Main Authors: Tonghui Huang, Jie Sun, Qianqian Wang, Jian Gao, Yi Liu
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Molecules
Subjects:
acetyl-CoA carboxylase
inhibitors
piperidinylpiperidines
spirochromanones
synthesis
molecular docking
Online Access:http://www.mdpi.com/1420-3049/20/9/16221

Internet

http://www.mdpi.com/1420-3049/20/9/16221

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