Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies

Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies

A series of novel pyran-linked phthalazinone-pyrazole hybrids were designed and synthesized by a facile one-pot three-component reaction employing substituted phthalazinone, 1H-pyrazole-5-carbaldehyde, and active methylene compounds. Optimization studies led to the identification of L-proline and et...

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Bibliographic Details
Main Authors: M. Shaheer Malik, Basim H. Asghar, Riyaz Syed, Reem I. Alsantali, Moataz Morad, Hatem M. Altass, Ziad Moussa, Ismail I. Althagafi, Rabab S. Jassas, Saleh A. Ahmed
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Chemistry
Subjects:
phthalazinone
pyrazole hybrids
pyran
multicomponent
anticancer activity
molecular modelling
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.666573/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.666573/full

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