Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision

Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision

TT-034 (PF-05095808) is a recombinant adeno-associated virus serotype 8 (AAV8) agent expressing three short hairpin RNA (shRNA) pro-drugs that target the hepatitis C virus (HCV) RNA genome. The cytosolic enzyme Dicer cleaves each shRNA into multiple, potentially active small interfering RNA (siRNA)...

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Bibliographic Details
Main Authors: Hubert Denise, Sterghios A. Moschos, Benjamin Sidders, Frances Burden, Hannah Perkins, Nikki Carter, Tim Stroud, Michael Kennedy, Sally-Ann Fancy, Cris Lapthorn, Helen Lavender, Ross Kinloch, David Suhy, Romu Corbau
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
HCV
mechanism of action
RACE-seq
siRNA
shRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116302864

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116302864

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