SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia

SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia

Abstract Background The differentiation-based therapy for acute promyelocytic leukemia (APL) is an inspiring example for the search of novel strategies aimed at treatment of other subtypes of acute myeloid leukemia (AML). Thus, the discovery of new molecular players in cell differentiation becomes a...

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Bibliographic Details
Main Authors: Alejandro Pérez-Fernández, Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Carla Ijurko, María Díez-Campelo, Fermín Sánchez-Guijo, Ángel Hernández-Hernández
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SHP1
SHP2
Cell differentiation
Phorbol esters
Acute myeloid leukemia
Pro-differentiating therapy
Online Access:http://link.springer.com/article/10.1186/s13046-019-1097-z

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http://link.springer.com/article/10.1186/s13046-019-1097-z

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