Inducible and combinatorial gene manipulation in mouse brain

Inducible and combinatorial gene manipulation in mouse brain

We have deployed recombinant adeno-associated viruses (rAAVs) equipped with tetracycline-controlled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination...

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Bibliographic Details
Main Authors: Godwin K Dogbevia, Ricardo eMarticorena-Alvarez, Melanie eBausen, Rolf eSprengel, Mazahir T Hasan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neurological Diseases
brain circuits
Learning and plasticity
Cre mediated recombination
rAAVs
Tetracycline inducible systems
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00142/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00142/full

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