Phase I/Ib Study of Tenalisib (RP6530), a Dual PI3K δ/γ Inhibitor in Patients with Relapsed/Refractory T-Cell Lymphoma

Phase I/Ib Study of Tenalisib (RP6530), a Dual PI3K δ/γ Inhibitor in Patients with Relapsed/Refractory T-Cell Lymphoma

Tenalisib (RP6530), a dual phosphoinositide 3-kinase δ/γ inhibitor was evaluated in a phase I/Ib study for maximum tolerated dose (MTD), pharmacokinetics, and efficacy in patients with relapsed/refractory peripheral and cutaneous T-Cell Lymphoma (TCL). Histologically confirmed (TCL) patients, with ≥...

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Bibliographic Details
Main Authors: Auris Huen, Bradley M. Haverkos, Jasmine Zain, Ramchandren Radhakrishnan, Mary Jo Lechowicz, Sumana Devata, Neil J. Korman, Lauren Pinter-Brown, Yasuhiro Oki, Prajak J. Barde, Ajit Nair, Kasi Viswanath Routhu, Srikant Viswanadha, Swaroop Vakkalanka, Swaminathan P. Iyer
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
maximum tolerated dose
dose limiting toxicity
PTCL
CTCL
Online Access:https://www.mdpi.com/2072-6694/12/8/2293

Internet

https://www.mdpi.com/2072-6694/12/8/2293

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