Fatty Acids Increase Neuronal Hypertrophy of PTEN Knockdown Neurons

Fatty Acids Increase Neuronal Hypertrophy of PTEN Knockdown Neurons

Phosphatase and tensin homolog (Pten) catalyzes the reverse reaction of PI3K by dephosphorylating PIP3 to PIP2. This negatively regulates downstream Akt/mTOR/S6 signaling resulting in decreased cellular growth and proliferation. Co-injection of a lentivirus knocking Pten down with a control lentiv...

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Bibliographic Details
Main Authors: Catherine J Fricano, Tyrone eDeSpenza, Paul eFrazel, Meijie eLi, James eO'Malley, Gary L Westbrook, Bryan Weston Luikart
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Dendrites
Dendritic Spines
Dentate Gyrus
Fatty Acids
Hypertrophy
autism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00030/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00030/full

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